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Which aromatase inhibitor is best? In studies of previously treated postmenopausal women with metastatic disease, the aromatase inhibitors were typically at least as effective as megestrol or tamoxifen. Anastrozole and letrozole both demonstrated improved survival compared with megestrol, and greater overall (complete and partial) response. Is weight gain a side effect of Arimidex? Studies have shown that weight gain is not increased in women taking tamoxifen or anastrozole, but it is harder to study the effects of these drugs on a woman's ability to lose weight. Regardless of the reasons for weight gain, weight loss requires calorie reduction.
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